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ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids.
Menghini, Rossella; Hoyles, Lesley; Cardellini, Marina; Casagrande, Viviana; Marino, Arianna; Gentileschi, Paolo; Davato, Francesca; Mavilio, Maria; Arisi, Ivan; Mauriello, Alessandro; Montanaro, Manuela; Scimeca, Manuel; Barton, Richard H; Rappa, Francesca; Cappello, Francesco; Vinciguerra, Manlio; Moreno-Navarrete, José Maria; Ricart, Wifredo; Porzio, Ottavia; Fernández-Real, José-Manuel; Burcelin, Rémy; Dumas, Marc-Emmanuel; Federici, Massimo.
Afiliación
  • Menghini R; Department of Systems Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
  • Hoyles L; Department of Biosciences, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom.
  • Cardellini M; Department of Systems Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
  • Casagrande V; Department of Systems Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
  • Marino A; Department of Systems Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
  • Gentileschi P; Department of Surgery, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
  • Davato F; Department of Systems Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
  • Mavilio M; Department of Systems Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
  • Arisi I; European Brain Research Institute (EBRI) "Rita Levi-Montalcini", Viale Regina Elena, 295, 00161, Rome, Italy; CNR, Institute of Translational Pharmacology (IFT), Via del Fosso del Cavaliere 100, 00131, Rome, Italy.
  • Mauriello A; Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
  • Montanaro M; Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
  • Scimeca M; Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
  • Barton RH; Imperial College London, Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom.
  • Rappa F; Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, Palermo, Italy; Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy.
  • Cappello F; Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, Palermo, Italy; Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy.
  • Vinciguerra M; International Clinical Research Center (FNUSA-ICRC), St Anne University Hospital, Brno, Czech Republic; Institute of Liver and Digestive Health, Division of Medicine, University College London (UCL), London, United Kingdom.
  • Moreno-Navarrete JM; Department of Diabetes, Endocrinology and Nutrition, University Hospital of Girona 'Dr Josep Trueta' Institut d'Investigacio Biomedica de Girona IdibGi; and CIBER Fisiopatologia de la Obesidad y Nutricion, Girona, Spain.
  • Ricart W; Department of Diabetes, Endocrinology and Nutrition, University Hospital of Girona 'Dr Josep Trueta' Institut d'Investigacio Biomedica de Girona IdibGi; and CIBER Fisiopatologia de la Obesidad y Nutricion, Girona, Spain.
  • Porzio O; Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
  • Fernández-Real JM; Department of Diabetes, Endocrinology and Nutrition, University Hospital of Girona 'Dr Josep Trueta' Institut d'Investigacio Biomedica de Girona IdibGi; and CIBER Fisiopatologia de la Obesidad y Nutricion, Girona, Spain; Department of Medical Sciences. School of Medicine, University of Girona, Spain
  • Burcelin R; INSERM and University Paul Sabatier: Institut des Maladies Métaboliques et Cardiovasculaires, INSERM U1048 F-31432 Toulouse, France and Université Paul Sabatier, F-31432, Toulouse, France.
  • Dumas ME; Imperial College London, Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom; Section of Genomic and Environmental Medicine, Respiratory Division, National Hear
  • Federici M; Department of Systems Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy; Center for Atherosclerosis, University Hospital "Policlinico Tor Vergata", Italy. Electronic address: federicm@uniroma2.it.
Mol Metab ; 59: 101454, 2022 05.
Article en En | MEDLINE | ID: mdl-35150905
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ubiquitina-Proteína Ligasas / Enfermedad del Hígado Graso no Alcohólico / Aminoácidos de Cadena Ramificada / Neoplasias Hepáticas / Obesidad Límite: Animals / Female / Humans Idioma: En Revista: Mol Metab Año: 2022 Tipo del documento: Article País de afiliación: Italia
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ubiquitina-Proteína Ligasas / Enfermedad del Hígado Graso no Alcohólico / Aminoácidos de Cadena Ramificada / Neoplasias Hepáticas / Obesidad Límite: Animals / Female / Humans Idioma: En Revista: Mol Metab Año: 2022 Tipo del documento: Article País de afiliación: Italia