A Preliminary Study for an Intraoperative 3D Bioprinting Treatment of Severe Burn Injuries.
Plast Reconstr Surg Glob Open
; 10(1): e4056, 2022 Jan.
Article
en En
| MEDLINE
| ID: mdl-35186622
ABSTRACT
Intraoperative three-dimensional fabrication of living tissues could be the next biomedical revolution in patient treatment. APPROACH:
We developed a surgery-ready robotic three-dimensional bioprinter and demonstrated that a bioprinting procedure using medical grade hydrogel could be performed using a 6-axis robotic arm in vivo for treating burn injuries.RESULTS:
We conducted a pilot swine animal study on a deep third-degree severe burn model. We observed that the use of cell-laden bioink as treatment substantially affects skin regeneration, producing in situ fibroblast growth factor and vascular endothelial growth factor, necessary for tissue regeneration and re-epidermalization of the wound.CONCLUSIONS:
We described an animal study of intraoperative three-dimensional bioprinting living tissue. This emerging technology brings the first proof of in vivo skin printing feasibility using a surgery-ready robotic arm-based bioprinter. Our positive outcome in skin regeneration, joined with this procedure's feasibility, allow us to envision the possibility of using this innovative approach in a human clinical trial in the near future.
Texto completo:
1
Banco de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Plast Reconstr Surg Glob Open
Año:
2022
Tipo del documento:
Article
País de afiliación:
Francia