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ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression.
Quek, Hazel; Cuní-López, Carla; Stewart, Romal; Colletti, Tiziana; Notaro, Antonietta; Nguyen, Tam Hong; Sun, Yifan; Guo, Christine C; Lupton, Michelle K; Roberts, Tara L; Lim, Yi Chieh; Oikari, Lotta E; La Bella, Vincenzo; White, Anthony R.
Afiliación
  • Quek H; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. Hazel.quek@qimrberghofer.edu.au.
  • Cuní-López C; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Stewart R; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Colletti T; ALS Clinical Research Centre and Laboratory of Neurochemistry, Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
  • Notaro A; ALS Clinical Research Centre and Laboratory of Neurochemistry, Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
  • Nguyen TH; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Sun Y; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Guo CC; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Lupton MK; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Roberts TL; Ingham Institute for Applied Medical Research and School of Medicine, Western Sydney University, Liverpool, NSW, Australia.
  • Lim YC; Brain Tumour Biology, Danish Cancer Society, Copenhagen, Denmark.
  • Oikari LE; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • La Bella V; ALS Clinical Research Centre and Laboratory of Neurochemistry, Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
  • White AR; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. Tony.White@qimrberghofer.edu.au.
J Neuroinflammation ; 19(1): 58, 2022 Feb 28.
Article en En | MEDLINE | ID: mdl-35227277
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Proteínas de Unión al ADN / Esclerosis Amiotrófica Lateral Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Neuroinflammation Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Australia
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Proteínas de Unión al ADN / Esclerosis Amiotrófica Lateral Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Neuroinflammation Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Australia