Synthetic lethality of cyclin-dependent kinase inhibitor Dinaciclib with <i>VHL</i>-deficiency allows for selective targeting of clear cell renal cell carcinoma.

Nelson, Luke J; Castro, Kyleen E; Xu, Binzhi; Li, Junyi; Dinh, Nguyen B; Thompson, Jordan M; Woytash, Jordan; Kipp, Kevin R; Razorenova, Olga V

Synthetic lethality of cyclin-dependent kinase inhibitor Dinaciclib with VHL-deficiency allows for selective targeting of clear cell renal cell carcinoma.

Nelson, Luke J; Castro, Kyleen E; Xu, Binzhi; Li, Junyi; Dinh, Nguyen B; Thompson, Jordan M; Woytash, Jordan; Kipp, Kevin R; Razorenova, Olga V.

Afiliación

Nelson LJ; Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA.
Castro KE; Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA.
Xu B; Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA.
Li J; Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA.
Dinh NB; Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA.
Thompson JM; Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA.
Woytash J; Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA.
Kipp KR; Bioniz Therapeutics, Irvine, California, USA.
Razorenova OV; Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA.

Cell Cycle ; 21(10): 1103-1119, 2022 05.

Article en En | MEDLINE | ID: mdl-35240916

Asunto(s)

Carcinoma de Células Renales; Neoplasias Renales; Animales; Carcinoma de Células Renales/genética; Línea Celular Tumoral; Óxidos N-Cíclicos; Proteínas Inhibidoras de las Quinasas Dependientes de la Ciclina/genética; Quinasas Ciclina-Dependientes/genética; Femenino; Humanos; Indolizinas; Neoplasias Renales/patología; Masculino; Ratones; Inhibidores de Proteínas Quinasas/farmacología; Inhibidores de Proteínas Quinasas/uso terapéutico; Compuestos de Piridinio; Mutaciones Letales Sintéticas; Proteína Supresora de Tumores del Síndrome de Von Hippel-Lindau/genética; Proteína Supresora de Tumores del Síndrome de Von Hippel-Lindau/metabolismo

Palabras clave

Dinaciclib; cyclin-dependent kinase; renal cell carcinoma; synthetic lethality; von-Hippel Lindau

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Neoplasias Renales Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Cycle Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google