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Ultrasound stimulation improves inflammatory resolution, neuroprotection, and functional recovery after spinal cord injury.
Hong, Yu-Ri; Lee, Eun-Hee; Park, Ki-Su; Han, Mun; Kim, Kyoung-Tae; Park, Juyoung.
Afiliación
  • Hong YR; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, Korea.
  • Lee EH; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, Korea.
  • Park KS; Department of Neurosurgery, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, Korea.
  • Han M; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, Korea.
  • Kim KT; Department of Neurosurgery, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, Korea. nskimkt7@gmail.com.
  • Park J; Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, Korea. opedoors@gmail.com.
Sci Rep ; 12(1): 3636, 2022 03 07.
Article en En | MEDLINE | ID: mdl-35256617
ABSTRACT
Spinal cord injury (SCI) is associated with limited functional recovery. Despite advances in neuroscience, realistic therapeutic treatments for SCI remain unavailable. In this study, the effects of non-invasive ultrasound (US) treatment on behavior and inflammatory responses were evaluated in a rat model of SCI. Adult female Sprague-Dawley rats were subjected to spinal cord contusion injury. Two different US parameters (SCIU5 5% and SCIU40 40% duty cycle) were applied, and their effects on behavioral recovery after SCI were quantified. Tissue and neuronal responses were detected. Immunofluorescence was used to detect inflammatory markers. In the rat model of SCI, motor function was more effectively restored, and the lesion cavity area was smaller in the SCIU5 group. Furthermore, the SCIU5 protocol elicited an anti-inflammatory response at the injury site by reducing degenerative FJC-labeled neurons, macrophage/microglia activation, and infiltration. Thus, the lesion area decreased, and tissue density increased. Meanwhile, the SCIU40 protocol did not improve motor function or induce an anti-inflammatory response at the injury site. The SCIU5 protocol effectively accelerated the rate of improved exercise performance in the rat model while reducing inflammation. Accordingly, appropriate US stimulation may represent a promising treatment modality for SCI with beneficial anti-inflammatory effects.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Neuroprotección Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Neuroprotección Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article