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Tuning the Elasticity of Nanogels Improves Their Circulation Time by Evading Immune Cells.
Desai, Prachi; Rimal, Rahul; Florea, Alexandru; Gumerov, Rustam A; Santi, Marta; Sorokina, Anastasia S; Sahnoun, Sabri E M; Fischer, Thorsten; Mottaghy, Felix M; Morgenroth, Agnieszka; Mourran, Ahmed; Potemkin, Igor I; Möller, Martin; Singh, Smriti.
Afiliación
  • Desai P; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.
  • Rimal R; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.
  • Florea A; Department of Nuclear Medicine, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany.
  • Gumerov RA; Department of Radiology and Nuclear Medicine, School for Cardiovascular Diseases (CARIM) and School for Oncology (GROW), Maastricht University, 6229 HX, Maastricht, The Netherlands.
  • Santi M; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.
  • Sorokina AS; Physics Department, Lomonosov Moscow State University, Leninskie Gory 1-2, 119991, Moscow, Russian Federation.
  • Sahnoun SEM; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.
  • Fischer T; Physics Department, Lomonosov Moscow State University, Leninskie Gory 1-2, 119991, Moscow, Russian Federation.
  • Mottaghy FM; Department of Nuclear Medicine, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany.
  • Morgenroth A; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.
  • Mourran A; Department of Nuclear Medicine, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany.
  • Potemkin II; Department of Radiology and Nuclear Medicine, School for Cardiovascular Diseases (CARIM) and School for Oncology (GROW), Maastricht University, 6229 HX, Maastricht, The Netherlands.
  • Möller M; Department of Nuclear Medicine, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany.
  • Singh S; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.
Angew Chem Int Ed Engl ; 61(20): e202116653, 2022 05 09.
Article en En | MEDLINE | ID: mdl-35274425
Peptide receptor radionuclide therapy is used to treat solid tumors by locally delivering radiation. However, due to nephro- and hepato-toxicity, it is limited by its dosage. To amplify radiation damage to tumor cells, radiolabeled nanogels can be used. We show that by tuning the mechanical properties of nanogels significant enhancement in circulation half-life of the gel could be achieved. We demonstrate why and how small changes in the mechanical properties of the nanogels influence its cellular fate. Nanogels with a storage modulus of 37 kPa were minimally phagocytosed by monocytes and macrophages compared to nanogels with 93 kPa modulus. Using PET/CT a significant difference in the blood circulation time of the nanogels was shown. Computer simulations affirmed the results and predicted the mechanism of cellular uptake of the nanogels. Altogether, this work emphasizes the important role of elasticity even for particles that are inherently soft such as nano- or microgels.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tomografía Computarizada por Tomografía de Emisión de Positrones / Microgeles Idioma: En Revista: Angew Chem Int Ed Engl Año: 2022 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tomografía Computarizada por Tomografía de Emisión de Positrones / Microgeles Idioma: En Revista: Angew Chem Int Ed Engl Año: 2022 Tipo del documento: Article País de afiliación: Alemania