Structural visual metrics associate with moderate to vigorous physical activity in youth with pediatric onset neuroinflammatory disorders.
Mult Scler Relat Disord
; 60: 103745, 2022 Apr.
Article
en En
| MEDLINE
| ID: mdl-35306241
ABSTRACT
BACKGROUND:
Higher levels of moderate to vigorous physical activity (MVPA) associate with disease activity in pediatric multiple sclerosis (MS). Further, measures of retinal integrity associate with lower brain atrophy, yet the relationship of retinal integrity with MVPA has not been investigated.OBJECTIVE:
To determine the relationship between MVPA and retinal nerve fibre layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness in patients with MS, myelin oligodendrocyte glycoprotein-associated disorders (MOGAD), neuromyelitis optica spectrum disorder (NMOSD), and monophasic acquired demyelinating syndromes (monoADS).METHODS:
150 consecutive children ≤18 y.o with neuroinflammatory disorders were included. Outcomes included the Godin Leisure Time Activity Questionnaire (GLTEQ) modeled as both a continuous and categorical variable (any vs no MVPA/Strenuous activity), and RNFL and GCIPL using linear mixed models (JASP 0.14.1).RESULTS:
An association was identified between MVPA with RNFL thickness (F (1,133) = 8.40, p = .004) and GCIPL thickness (F(1, 131) = 7.68, p = .006). In the MS cohort, any strenuous physical activity was associated with greater RNFL (F(1,35) = 7.30, p = .011) and GCIPL thickness (F(1,35) = 8.73, p =.006).CONCLUSIONS:
Any MVPA participation is associated with higher RNFL and GCIPL thickness across neuroinflammatory disorders.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Ganglionares de la Retina
/
Esclerosis Múltiple
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Humans
Idioma:
En
Revista:
Mult Scler Relat Disord
Año:
2022
Tipo del documento:
Article
País de afiliación:
Canadá