Visible-Light-Induced Alkylarylation of Unactivated Alkenes via Radical Addition/Truce-Smiles Rearrangement Cascade.
Org Lett
; 24(14): 2767-2771, 2022 Apr 15.
Article
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| MEDLINE
| ID: mdl-35377660
ABSTRACT
We disclosed a visible-light-induced alkylarylation reaction of unactivated alkenes via a metal-free radical addition/aryl translocation cascade sequence. Distal olefinic sulfonate was designed as a unique molecular scaffold allowing for a domino process to synthesize valuable alkylarylated alcohols in good yields with excellent diastereoselectivity, featuring mild reaction conditions, broad substrate scope, and excellent functional group tolerance. The mechanism investigation suggests that a visible-light-induced radical chain process dominates the cascade transformation.
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Banco de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
China