The Evidence for Effective Inhibition of INa Produced by Mirogabalin ((1R,5S,6S)-6-(aminomethyl)-3-ethyl-bicyclo [3.2.0] hept-3-ene-6-acetic acid), a Known Blocker of CaV Channels.

Wu, Chao-Liang; Chuang, Chao-Wei; Cho, Hsin-Yen; Chuang, Tzu-Hsien; Wu, Sheng-Nan

The Evidence for Effective Inhibition of I_Na Produced by Mirogabalin ((1R,5S,6S)-6-(aminomethyl)-3-ethyl-bicyclo [3.2.0] hept-3-ene-6-acetic acid), a Known Blocker of Ca_V Channels.

Wu, Chao-Liang; Chuang, Chao-Wei; Cho, Hsin-Yen; Chuang, Tzu-Hsien; Wu, Sheng-Nan.

Afiliación

Wu CL; Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 60002, Taiwan.
Chuang CW; Department of Ophthalmology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 60002, Taiwan.
Cho HY; Department of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan.
Chuang TH; Department of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan.
Wu SN; Department of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan.

Int J Mol Sci ; 23(7)2022 Mar 31.

Article en En | MEDLINE | ID: mdl-35409204

Asunto(s)

Ácido Acético; Neoplasias Hipofisarias; Compuestos Bicíclicos con Puentes; Humanos; Neoplasias Hipofisarias/patología; Sodio

Palabras clave

current kinetics; hysteresis; mirogabalin (Tarlige®, 1R,5S,6S)-6-(aminomethyl)-3-ethyl-bicyclo [3.2.0] hept-3-ene-6-acetic acid); persistent Na+ current; pulse train stimulation; resurgent Na+ current; voltage-gated Na+ current; window Na+ current

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Hipofisarias / Ácido Acético Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Taiwán

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