Making Antimicrobial Susceptibility Testing More Physiologically Relevant with Bicarbonate?
Antimicrob Agents Chemother
; 66(5): e0241221, 2022 05 17.
Article
en En
| MEDLINE
| ID: mdl-35435706
ABSTRACT
Azithromycin is a clinically important drug for treating invasive salmonellosis despite poor activity in laboratory assays for MIC. Addition of the main buffer in blood, bicarbonate, has been proposed for more physiologically relevant and more predictive testing conditions. However, we show here that bicarbonate-triggered lowering of azithromycin MIC is entirely due to alkalization of insufficiently buffered media. In addition, bicarbonate is unlikely to be altering efflux pump activity.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Azitromicina
/
Antiinfecciosos
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estonia