Real-time monitoring of antibody quality attributes for cell culture production processes in bioreactors via integration of an automated sampling technology with multi-dimensional liquid chromatography mass spectrometry.

Dahotre, Sanket; Dai, Lu; Kjenstad, Karissa; Stella, Cinzia; Camperi, Julien

Dahotre, Sanket; Dai, Lu; Kjenstad, Karissa; Stella, Cinzia; Camperi, Julien.

Afiliación

Dahotre S; iLabs, Genentech, 1 DNA Way, South San Francisco, CA 94080, United States.
Dai L; Protein Analytical Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, United States.
Kjenstad K; Digital Sciences, Genentech, 1 DNA Way, South San Francisco, CA 98040, United States.
Stella C; Protein Analytical Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, United States.
Camperi J; Protein Analytical Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: camperi.julien@gene.com.

J Chromatogr A ; 1672: 463067, 2022 Jun 07.

Article en En | MEDLINE | ID: mdl-35462311

Asunto(s)

Anticuerpos Monoclonales; Espectrometría de Masas en Tándem; Anticuerpos Monoclonales/química; Automatización; Reactores Biológicos; Técnicas de Cultivo de Célula; Cromatografía Liquida/métodos

Palabras clave

Bioreactor; Fc-fusion protein; Quality attributes; Real-time monitoring; Sialylation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Espectrometría de Masas en Tándem / Anticuerpos Monoclonales Idioma: En Revista: J Chromatogr A Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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