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Regional CAR T cell therapy: An ignition key for systemic immunity in solid tumors.
Cherkassky, Leonid; Hou, Zhaohua; Amador-Molina, Alfredo; Adusumilli, Prasad S.
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  • Cherkassky L; Department of Surgical Oncology and Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
  • Hou Z; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Amador-Molina A; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Adusumilli PS; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: adusumip@mskcc.org.
Cancer Cell ; 40(6): 569-574, 2022 06 13.
Article en En | MEDLINE | ID: mdl-35487216
ABSTRACT
The success of chimeric antigen receptor (CAR) T cell therapy in solid tumors, unlike in hematologic malignancies, is limited by inadequate tumor infiltration and T cell dysfunction and exhaustion. Regional delivery of CAR T cells in patients with solid tumors is safe and feasible; promotes infiltration, proliferation, and trafficking; and ignites functionally persisting systemic immunity.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores Quiméricos de Antígenos / Neoplasias Límite: Humans Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores Quiméricos de Antígenos / Neoplasias Límite: Humans Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos