Evaluation of a long-acting injectable formulation of omeprazole in healthy dogs.
J Vet Intern Med
; 36(4): 1416-1421, 2022 Jul.
Article
en En
| MEDLINE
| ID: mdl-35546514
ABSTRACT
BACKGROUND:
To evaluate the efficacy of a single intramuscular adminsitration of long-acting omeprazole (LA-OMEP) in increasing gastric pH in dogs.HYPOTHESIS:
We hypothesized that LA-OMEP would meet in healthy dogs the clinical goals defined for human patients for treatment of gastroduodenal ulceration. ANIMALS Nine healthy research dogs.METHODS:
Prospective experimental study. Dogs were given a 4 mg/kg intramuscular injection of LA-OMEP. Intragastric pH was continuously recorded on treatment days 0 to 7. Daily mean pH and mean percentage time (MPT) intragastric pH was ≥3 or ≥4 were determined.RESULTS:
The mean onset of action for the LA-OMEP was 98.11 min (SD 46.39). The mean number of days the dogs' pH met established goals for MPT pH ≥3 was 5.5 days (range, 3-7) and 5.25 days for MPT pH ≥4 (range, 3-7). Long-acting omeprazole met the human clinical goals pH ≥3 for 72 hours in 8/8 of the dogs and MPT pH ≥4 for 96 hours in 7/8 of dogs. CONCLUSIONS AND CLINICAL IMPORTANCE The LA-OMEP formulation produced gastric acid suppression in healthy dogs for an average of 5 days and up to 7 days, after a single intramuscular injection. No major adverse effects were observed.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Omeprazol
/
Antiulcerosos
Tipo de estudio:
Clinical_trials
/
Observational_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Vet Intern Med
Asunto de la revista:
MEDICINA INTERNA
/
MEDICINA VETERINARIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos