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Disrupting autorepression circuitry generates "open-loop lethality" to yield escape-resistant antiviral agents.
Chaturvedi, Sonali; Pablo, Michael; Wolf, Marie; Rosas-Rivera, Daniel; Calia, Giuliana; Kumar, Arjun J; Vardi, Noam; Du, Kelvin; Glazier, Joshua; Ke, Ruian; Chan, Matilda F; Perelson, Alan S; Weinberger, Leor S.
Afiliación
  • Chaturvedi S; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA 94158, USA. Electronic address: sonali.chaturvedi@gladstone.ucsf.edu.
  • Pablo M; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Wolf M; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Rosas-Rivera D; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Calia G; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Kumar AJ; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Vardi N; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Du K; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Glazier J; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA 94158, USA.
  • Ke R; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
  • Chan MF; Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Perelson AS; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
  • Weinberger LS; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; Departm
Cell ; 185(12): 2086-2102.e22, 2022 06 09.
Article en En | MEDLINE | ID: mdl-35561685
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Regulación Viral de la Expresión Génica Límite: Animals Idioma: En Revista: Cell Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Regulación Viral de la Expresión Génica Límite: Animals Idioma: En Revista: Cell Año: 2022 Tipo del documento: Article