DOCK2 contributes to pulmonary fibrosis by promoting lung fibroblast to myofibroblast transition.

Guo, Xia; Adeyanju, Oluwaseun; Sunil, Christudas; Mandlem, Venkatakirankumar; Olajuyin, Ayobami; Huang, Steven; Chen, Shi-You; Idell, Steven; Tucker, Torry A; Qian, Guoqing

Guo, Xia; Adeyanju, Oluwaseun; Sunil, Christudas; Mandlem, Venkatakirankumar; Olajuyin, Ayobami; Huang, Steven; Chen, Shi-You; Idell, Steven; Tucker, Torry A; Qian, Guoqing.

Afiliación

Guo X; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.
Adeyanju O; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.
Sunil C; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.
Mandlem V; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.
Olajuyin A; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.
Huang S; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The University of Michigan-Ann Arbor, Ann Arbor, Michigan.
Chen SY; Department of Surgery, School of Medicine, The University of Missouri, Columbia, Missouri.
Idell S; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.
Tucker TA; The Texas Lung Injury Institute, Tyler, Texas.
Qian G; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas.

Am J Physiol Cell Physiol ; 323(1): C133-C144, 2022 07 01.

Article en En | MEDLINE | ID: mdl-35584329

Asunto(s)

Fibroblastos; Proteínas Activadoras de GTPasa; Factores de Intercambio de Guanina Nucleótido; Fibrosis Pulmonar Idiopática; Miofibroblastos; Actinas/genética; Actinas/metabolismo; Animales; Bleomicina/toxicidad; Células Cultivadas; Modelos Animales de Enfermedad; Fibroblastos/metabolismo; Fibroblastos/patología; Proteínas Activadoras de GTPasa/genética; Proteínas Activadoras de GTPasa/metabolismo; Factores de Intercambio de Guanina Nucleótido/genética; Factores de Intercambio de Guanina Nucleótido/metabolismo; Humanos; Fibrosis Pulmonar Idiopática/inducido químicamente; Fibrosis Pulmonar Idiopática/genética; Fibrosis Pulmonar Idiopática/metabolismo; Fibrosis Pulmonar Idiopática/fisiopatología; Pulmón/metabolismo; Pulmón/patología; Pulmón/fisiopatología; Ratones; Ratones Endogámicos C57BL; Miofibroblastos/metabolismo; Miofibroblastos/patología; Factor de Crecimiento Transformador beta/genética; Factor de Crecimiento Transformador beta/metabolismo

Palabras clave

DOCK2; TGF-ß; fibroblast to myofibroblast transition; lung; pulmonary fibrosis

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Activadoras de GTPasa / Factores de Intercambio de Guanina Nucleótido / Fibrosis Pulmonar Idiopática / Miofibroblastos / Fibroblastos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Am J Physiol Cell Physiol Asunto de la revista: FISIOLOGIA Año: 2022 Tipo del documento: Article

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