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Application of Neurotoxin-Induced Animal Models in the Study of Parkinson's Disease-Related Depression: Profile and Proposal.
Mou, Ya-Kui; Guan, Li-Na; Yao, Xiao-Yan; Wang, Jia-Hui; Song, Xiao-Yu; Ji, Yong-Qiang; Ren, Chao; Wei, Shi-Zhuang.
Afiliación
  • Mou YK; Department of Otolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
  • Guan LN; Department of Neurosurgical Intensive Care Unit, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
  • Yao XY; Department of Neurology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
  • Wang JH; Department of Central Laboratory, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
  • Song XY; Department of Otolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
  • Ji YQ; Department of Nephrology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
  • Ren C; Department of Otolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
  • Wei SZ; Department of Neurology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
Front Aging Neurosci ; 14: 890512, 2022.
Article en En | MEDLINE | ID: mdl-35645772
ABSTRACT
Depression can be a non-motor symptom, a risk factor, and even a co-morbidity of Parkinson's disease (PD). In either case, depression seriously affects the quality of life of PD patients. Unfortunately, at present, a large number of clinical and basic studies focused on the pathophysiological mechanism of PD and the prevention and treatment of motor symptoms. Although there has been increasing attention to PD-related depression, it is difficult to achieve early detection and early intervention, because the clinical guidelines mostly refer to depression developed after or accompanied by motor impairments. Why is there such a dilemma? This is because there has been no suitable preclinical animal model for studying the relationship between depression and PD, and the assessment of depressive behavior in PD preclinical models is as well a very challenging task since it is not free from the confounding from the motor impairment. As a common method to simulate PD symptoms, neurotoxin-induced PD models have been widely used. Studies have found that neurotoxin-induced PD model animals could exhibit depression-like behaviors, which sometimes manifested earlier than motor impairments. Therefore, there have been attempts to establish the PD-related depression model by neurotoxin induction. However, due to a lack of unified protocol, the reported results were diverse. For the purpose of further promoting the improvement and optimization of the animal models and the study of PD-related depression, we reviewed the establishment and evaluation strategies of the current animal models of PD-related depression based on both the existing literature and our own research experience, and discussed the possible mechanism and interventions, in order to provide a reference for future research in this area.
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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Guideline / Prognostic_studies / Risk_factors_studies / Screening_studies Idioma: En Revista: Front Aging Neurosci Año: 2022 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Guideline / Prognostic_studies / Risk_factors_studies / Screening_studies Idioma: En Revista: Front Aging Neurosci Año: 2022 Tipo del documento: Article País de afiliación: China