A peptide blocking the ADORA1-neurabin interaction is anticonvulsant and inhibits epilepsy in an Alzheimer's model.

Saggu, Shalini; Chen, Yunjia; Chen, Liping; Pizarro, Diana; Pati, Sandipan; Law, Wen Jing; McMahon, Lori; Jiao, Kai; Wang, Qin

Saggu, Shalini; Chen, Yunjia; Chen, Liping; Pizarro, Diana; Pati, Sandipan; Law, Wen Jing; McMahon, Lori; Jiao, Kai; Wang, Qin.

Afiliación

Saggu S; Departments of Cell, Developmental and Integrative Biology.
Chen Y; Departments of Cell, Developmental and Integrative Biology.
Chen L; Departments of Cell, Developmental and Integrative Biology.
Pizarro D; Department of Neurology, and.
Pati S; Department of Neurology, and.
Law WJ; Departments of Cell, Developmental and Integrative Biology.
McMahon L; Departments of Cell, Developmental and Integrative Biology.
Jiao K; Department of Genetics, University of Alabama at Birmingham, Alabama, USA.
Wang Q; Departments of Cell, Developmental and Integrative Biology.

JCI Insight ; 7(11)2022 06 08.

Article en En | MEDLINE | ID: mdl-35674133

Asunto(s)

Enfermedad de Alzheimer; Epilepsia; Proteínas RGS; Adenosina; Enfermedad de Alzheimer/tratamiento farmacológico; Animales; Anticonvulsivantes/farmacología; Anticonvulsivantes/uso terapéutico; Epilepsia/tratamiento farmacológico; Humanos; Ratones; Proteínas de Microfilamentos; Proteínas del Tejido Nervioso; Proteínas RGS/metabolismo; Receptor de Adenosina A1/metabolismo

Palabras clave

Epilepsy; G protein–coupled receptors; Neuroscience; Pharmacology; Therapeutics

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas RGS / Epilepsia / Enfermedad de Alzheimer Límite: Animals / Humans Idioma: En Revista: JCI Insight Año: 2022 Tipo del documento: Article

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