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The Role of CD4+CD8+ T Cells in HIV Infection With Tuberculosis.
Zou, Shi; Tan, Yuting; Xiang, Yanni; Liu, Yang; Zhu, Qi; Wu, Songjie; Guo, Wei; Luo, Mingqi; Shen, Ling; Liang, Ke.
Afiliación
  • Zou S; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Tan Y; Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China.
  • Xiang Y; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Liu Y; Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China.
  • Zhu Q; Department of Intensive Care Medicine, Yichang Central People's Hospital, Yichang, China.
  • Wu S; Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
  • Guo W; School of Economics and Management, Wuhan University, Wuhan, China.
  • Luo M; Wuhan Pulmonary Hospital, Wuhan Institute for Tuberculosis Control, Wuhan, China.
  • Shen L; Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China.
  • Liang K; Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, China.
Front Public Health ; 10: 895179, 2022.
Article en En | MEDLINE | ID: mdl-35712309
Background: Tuberculosis (TB) is an important opportunistic infection in acquired immunodeficiency diseases (AIDS). Although the frequency of CD4+CD8+ double-positive (DP) T cells has been observed to increase in pathological conditions, their role (phenotypic and functional) is poorly described, especially in human immunodeficiency virus (HIV) infection with TB (HIV/TB (HT) coinfection). Methods: The percentage and phenotypic and functional properties of peripheral blood DP T cells in patients with HT coinfection in comparison to uninfected controls and to patients with HIV or TB mono-infection were analyzed by direct intracellular cytokine staining (ICS). Results: Total and CD4lowCD8high DP T cells were significantly increased in patients with both HIV and TB mono-infection, especially in patients with HT coinfection. Compared with healthy controls (HCs), the percentage of DP T cells expressing chemokine receptor 5 (CCR5) in patients with HT coinfection was significantly higher. Compared with HCs and patients with TB, a lower percentage of tumor necrosis factor α (TNF-α) secreting DP T cells and a higher percentage of granzyme A-secreting DP T cells were observed in patients with HIV mono-infection and HT coinfection, respectively. In addition, DP T cells expressed more cytolytic markers (granzyme A and perforin) than CD4+ T cells, but similarly to CD8+ T cells in patients with HT coinfection. Conclusions: Our data suggested that HT coinfection resulted in a marked increase in DP T cells, especially the CD4lowCD8high subpopulation. DP T cells may be susceptible to HT coinfection, and have the same cytotoxic function as CD8+ T cells.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tuberculosis / Linfocitos T CD4-Positivos / Infecciones por VIH / Linfocitos T CD8-positivos Límite: Humans Idioma: En Revista: Front Public Health Año: 2022 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tuberculosis / Linfocitos T CD4-Positivos / Infecciones por VIH / Linfocitos T CD8-positivos Límite: Humans Idioma: En Revista: Front Public Health Año: 2022 Tipo del documento: Article País de afiliación: China