Orthogonal Access to α-/ß-Branched/Linear Aliphatic Amines by Catalyst-Tuned Regiodivergent Hydroalkylations.
Angew Chem Int Ed Engl
; 61(34): e202208018, 2022 08 22.
Article
en En
| MEDLINE
| ID: mdl-35726965
ABSTRACT
Linear, α-branched, and ß-branched aliphatic amines are widespread in pharmaceuticals, agrochemicals, and fine chemicals. Thus, the development of direct and efficient methods to these structures in a tunable manner is highly desirable yet challenging. Herein, a catalyst-controlled synthesis of α-branched, ß-branched and linear aliphatic amines from Ni/Co-catalyzed regio- and site-selective hydroalkylations of alkenyl amines with alkyl halides is developed. This catalytic protocol features the reliable prediction and control of the coupling position of alkylation to provide orthogonal access to α-branched, ß-branched and linear alkyl amines from identical starting materials. This platform unlocks orthogonal reactivity and selectivity of nickel hydride and cobalt hydride chemistry to catalytically repurpose three types of alkyl amines under mild conditions.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aminas
/
Níquel
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2022
Tipo del documento:
Article