Placental Injury and Antibody Transfer after Coronavirus Disease 2019 in Pregnancy.
J Infect Dis
; 227(7): 850-854, 2023 04 12.
Article
en En
| MEDLINE
| ID: mdl-35767286
ABSTRACT
BACKGROUND:
We examined the relationship between placental histopathology and transplacental antibody transfer in pregnant patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.METHODS:
Differences in plasma concentrations of anti-receptor biding domain (RBD) immunoglobulin (Ig)G antibodies in maternal and cord blood were analyzed according to presence of placental injury.RESULTS:
Median anti-RBD IgG concentrations in cord blood with placental injury (n = 7) did not differ significantly from those without injury (n = 16) (median 2.7 [interquartile range {IQR}, 1.8-3.6] vs 2.7 [IQR, 2.4-2.9], P = 0.59). However, they were associated with lower transfer ratios (median 0.77 [IQR, 0.61-0.97] vs 0.97 [IQR, 0.80-1.01], P = 0.05).CONCLUSIONS:
SARS-CoV-2 placental injury may mediate reduced maternal-fetal antibody transfer.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
/
COVID-19
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Infect Dis
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos