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Increased atherosclerosis in a mouse model of glycogen storage disease type 1a.
La Rose, Anouk M; Groenen, Anouk G; Halmos, Benedek; Bazioti, Venetia; Rutten, Martijn G S; Krishnamurthy, Kishore A; Koster, Mirjam H; Kloosterhuis, Niels J; Smit, Marieke; Havinga, Rick; Mithieux, Gilles; Rajas, Fabienne; Kuipers, Folkert; Oosterveer, Maaike H; Westerterp, Marit.
Afiliación
  • La Rose AM; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Groenen AG; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Halmos B; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Bazioti V; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Rutten MGS; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Krishnamurthy KA; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Koster MH; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Kloosterhuis NJ; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Smit M; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Havinga R; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Mithieux G; Université Claude Bernard Lyon 1, Université de Lyon, INSERM UMR-S1213, Lyon, France.
  • Rajas F; Université Claude Bernard Lyon 1, Université de Lyon, INSERM UMR-S1213, Lyon, France.
  • Kuipers F; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Oosterveer MH; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Westerterp M; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Mol Genet Metab Rep ; 31: 100872, 2022 Jun.
Article en En | MEDLINE | ID: mdl-35782606
Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Mol Genet Metab Rep Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Mol Genet Metab Rep Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos