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Comprehensive Proteomics Profiling Identifies Patients With Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging in the Hypertrophic Cardiomyopathy Population.
Lander, Bradley S; Zhao, Yanling; Hasegawa, Kohei; Maurer, Mathew S; Tower-Rader, Albree; Fifer, Michael A; Reilly, Muredach P; Shimada, Yuichi J.
Afiliación
  • Lander BS; Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, United States.
  • Zhao Y; Department of Surgery, Columbia University Irving Medical Center, New York, NY, United States.
  • Hasegawa K; Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
  • Maurer MS; Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, United States.
  • Tower-Rader A; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
  • Fifer MA; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
  • Reilly MP; Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, United States.
  • Shimada YJ; Irving Institute for Clinical and Translational Research, Columbia University Irving Medical Center, New York, NY, United States.
Front Cardiovasc Med ; 9: 839409, 2022.
Article en En | MEDLINE | ID: mdl-35783832
Introduction: In hypertrophic cardiomyopathy (HCM), late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) represents myocardial fibrosis and is associated with sudden cardiac death. However, CMR requires particular expertise and is expensive and time-consuming. Therefore, it is important to specify patients with a high pre-test probability of having LGE as the utility of CMR is higher in such cases. The objective was to determine whether plasma proteomics profiling can distinguish patients with and without LGE on CMR in the HCM population. Materials and Methods: We performed a multicenter case-control (LGE vs. no LGE) study of 147 patients with HCM. We performed plasma proteomics profiling of 4,979 proteins. Using the 17 most discriminant proteins, we performed logistic regression analysis with elastic net regularization to develop a discrimination model with data from one institution (the training set; n = 111) and tested the discriminative ability in independent samples from the other institution (the test set; n = 36). We calculated the area under the receiver-operating-characteristic curve (AUC), sensitivity, and specificity. Results: Overall, 82 of the 147 patients (56%) had LGE on CMR. The AUC of the 17-protein model was 0.83 (95% confidence interval [CI], 0.75-0.90) in the training set and 0.71 in the independent test set for validation (95% CI, 0.54-0.88). The sensitivity of the training model was 0.72 (95% CI, 0.61-0.83) and the specificity was 0.78 (95% CI, 0.66-0.90). The sensitivity was 0.71 (95% CI, 0.49-0.92) and the specificity was 0.74 (95% CI, 0.54-0.93) in the test set. Based on the discrimination model derived from the training set, patients in the test set who had high probability of having LGE had a significantly higher odds of having LGE compared to those who had low probability (odds ratio 29.6; 95% CI, 1.6-948.5; p = 0.03). Conclusions: In this multi-center case-control study of patients with HCM, comprehensive proteomics profiling of 4,979 proteins demonstrated a high discriminative ability to distinguish patients with and without LGE. By identifying patients with a high pretest probability of having LGE, the present study serves as the first step to establishing a panel of circulating protein biomarkers to better inform clinical decisions regarding CMR utilization.
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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Cardiovasc Med Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Cardiovasc Med Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos