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Update on thyroid eye disease: Regional variations in prevalence, diagnosis, and management.
Yu, Caroline Y; Ford, Rebecca L; Wester, Sara T; Shriver, Erin M.
Afiliación
  • Yu CY; Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA.
  • Ford RL; Department of Ophthalmology, Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
  • Wester ST; Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Shriver EM; Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA.
Indian J Ophthalmol ; 70(7): 2335-2345, 2022 07.
Article en En | MEDLINE | ID: mdl-35791115
ABSTRACT
Thyroid eye disease (TED) is a rare disease that can lead to decreased quality of life, permanent disfigurement, and vision loss. Clinically, TED presents with exophthalmos, periorbital edema, extraocular muscle dysfunction, and eyelid retraction, and can lead to vision-threatening complications such as exposure to keratopathy and dysthyroid optic neuropathy (DON). Over the last several years, significant advancements have been made in the understanding of its pathophysiology as well as optimal management. Ethnic variations in the prevalence, clinical presentation, and risk of vision-threatening complications of TED are summarized, and risk factors associated with TED are discussed. Additionally, significant advances have been made in the management of TED. The management of TED traditionally included anti-inflammatory medications, orbital radiation therapy, orbital surgical decompression, and biologic therapies. Most recently, targeted therapies such as teprotumumab, an insulin-like growth factor-1 receptor antagonist, have been studied in the context of TED, with promising initial data. In this review, updates in the understanding and management of TED are presented with a focus on the international variations in presentation and management.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oftalmopatía de Graves Tipo de estudio: Diagnostic_studies / Etiology_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Indian J Ophthalmol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oftalmopatía de Graves Tipo de estudio: Diagnostic_studies / Etiology_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Indian J Ophthalmol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos