Evidence for Dual Activation of IK(M) and IK(Ca) Caused by QO-58 (5-(2,6-Dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)-1H-pyrazolol[1,5-a]pyrimidin-7-one).

Wu, Chao-Liang; Fu, Poyuan; Cho, Hsin-Yen; Chuang, Tzu-Hsien; Wu, Sheng-Nan

Evidence for Dual Activation of I_K(M) and I_K(Ca) Caused by QO-58 (5-(2,6-Dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)-1H-pyrazolol[1,5-a]pyrimidin-7-one).

Wu, Chao-Liang; Fu, Poyuan; Cho, Hsin-Yen; Chuang, Tzu-Hsien; Wu, Sheng-Nan.

Afiliación

Wu CL; Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 60002, Taiwan.
Fu P; Department of Ophthalmology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 60002, Taiwan.
Cho HY; Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.
Chuang TH; Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.
Wu SN; Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.

Int J Mol Sci ; 23(13)2022 Jun 24.

Article en En | MEDLINE | ID: mdl-35806047

Asunto(s)

Neoplasias Hipofisarias; Humanos; Técnicas de Placa-Clamp; Neoplasias Hipofisarias/patología

Palabras clave

5-(2,6-dichloro-5-fluoro-3-pyridinyl)-3-phenyl-2-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidin-7(4H)-one); Ca2+-activated K+ current; M-type K+ channel; M-type K+ current; QO-58 (5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)-1H-pyrazolol[1,5-a]pyrimidin-7-one; large-conductance Ca2+-activated K+ channel; voltage-dependent hysteresis

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Hipofisarias Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Taiwán

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