Optimizing study design in LPS challenge studies for quantifying drug induced inhibition of TNF&#945; response: Did we miss the prime time?

Larsson, Julia; Hoppe, Edmund; Gautrois, Michael; Cvijovic, Marija; Jirstrand, Mats

Optimizing study design in LPS challenge studies for quantifying drug induced inhibition of TNFα response: Did we miss the prime time?

Larsson, Julia; Hoppe, Edmund; Gautrois, Michael; Cvijovic, Marija; Jirstrand, Mats.

Afiliación

Larsson J; Fraunhofer-Chalmers Centre, Chalmers Science Park, Gothenburg 412 88, Sweden; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg 412 96, Sweden. Electronic address: julia.larsson@fcc.chalmers.se.
Hoppe E; Grünenthal GmbH, Aachen, Germany.
Gautrois M; Grünenthal GmbH, Aachen, Germany.
Cvijovic M; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg 412 96, Sweden.
Jirstrand M; Fraunhofer-Chalmers Centre, Chalmers Science Park, Gothenburg 412 88, Sweden.

Eur J Pharm Sci ; 176: 106256, 2022 Sep 01.

Article en En | MEDLINE | ID: mdl-35820630

Asunto(s)

Lipopolisacáridos; Factor de Necrosis Tumoral alfa; Lipopolisacáridos/farmacología; Proyectos de Investigación

Palabras clave

Lipopolysaccharides; Non-linear mixed effects modeling; Optimal design; Pharmacokinetics and pharmacodynamics; Tumor necrosis factor alpha

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Lipopolisacáridos / Factor de Necrosis Tumoral alfa Tipo de estudio: Guideline / Prognostic_studies Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2022 Tipo del documento: Article

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