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Brain structural alterations in autism and criminal psychopathy.
Noppari, Tuomo; Sun, Lihua; Lukkarinen, Lasse; Putkinen, Vesa; Tani, Pekka; Lindberg, Nina; Saure, Emma; Lauerma, Hannu; Tiihonen, Jari; Venetjoki, Niina; Salomaa, Marja; Rautio, Päivi; Hirvonen, Jussi; Salmi, Juha; Nummenmaa, Lauri.
Afiliación
  • Noppari T; Turku PET Centre, University of Turku, Turku, Finland; Department of Psychiatry, Helsinki University Hospital, Helsinki, Finland. Electronic address: tuomo.noppari@hus.fi.
  • Sun L; Turku PET Centre, University of Turku, Turku, Finland; Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai, China.
  • Lukkarinen L; Turku PET Centre, University of Turku, Turku, Finland.
  • Putkinen V; Turku PET Centre, University of Turku, Turku, Finland.
  • Tani P; Department of Psychiatry, Helsinki University Hospital, Helsinki, Finland.
  • Lindberg N; Department of Forensic Psychiatry, Helsinki University Hospital, Helsinki, Finland.
  • Saure E; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland; BABA Center and Department of Clinical Neurophysiology, Children's Hospital, Helsinki University Hospital and University of Helsinki, Finland.
  • Lauerma H; Psychiatric Hospital for Prisoners, Health Care Services for Prisoners, Turku, Finland; Department of Forensic Psychiatry, Turku University Central Hospital, Finland.
  • Tiihonen J; Department of Clinical Neuroscience, Karolinska Institute and Center for Psychiatry Research, Stockholm, Sweden; Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland; Neuroscience Center, University of Helsinki, Helsinki, Finland.
  • Venetjoki N; Psychiatric Hospital for Prisoners, Health Care Services for Prisoners, Turku, Finland.
  • Salomaa M; Psychiatric Hospital for Prisoners, Health Care Services for Prisoners, Turku, Finland.
  • Rautio P; Psychiatric Hospital for Prisoners, Health Care Services for Prisoners, Turku, Finland.
  • Hirvonen J; Department of Radiology, Turku University Hospital, Turku, Finland.
  • Salmi J; Department of Neuroscience and Biomedical Engineering, School of Science, Aalto University, Espoo, Finland.
  • Nummenmaa L; Turku PET Centre, University of Turku, Turku, Finland; Department of Psychology, University of Turku, Turku, Finland.
Neuroimage Clin ; 35: 103116, 2022.
Article en En | MEDLINE | ID: mdl-35872437
ABSTRACT
The goal of this study was to elucidate the anatomical brain basis of social cognition through two disorders with distinctively different phenotypes of social interaction. We compared structural MR images of 20 individuals with autism spectrum disorder (ASD), 19 violent offenders with high psychopathic traits, and 19 control participants using voxel-based morphometry (VBM). Our earlier study showed lower grey matter volume (GMV) values in the insula, frontal cortex, and sensorimotor cortex of the offender group compared to controls. In the present study, the images of the ASD group revealed lower GMV in the left precuneus, right cerebellum, and right precentral gyrus in comparison with controls. The comparison between the offender and ASD groups showed lower GMV values for the right temporal pole and left inferior frontal gyrus in the offender group. There was also an overlap of both disorders in the right pre-central cortex, showing lower GMV compared to controls. Our findings suggest structural differences between violent offenders with high psychopathy traits and ASD individuals in the frontotemporal social brain network areas, previously associated with empathy. We also provide evidence of similar abnormal structures in the motor cortex for both of these disorders, possibly related to uniting issues of social cognition.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastorno Autístico / Criminales / Trastorno del Espectro Autista Límite: Humans Idioma: En Revista: Neuroimage Clin Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastorno Autístico / Criminales / Trastorno del Espectro Autista Límite: Humans Idioma: En Revista: Neuroimage Clin Año: 2022 Tipo del documento: Article