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Distinctions Between Fecal and Intestinal Mucosal Microbiota in Subgroups of Irritable Bowel Syndrome.
Hou, Yangfan; Dong, Lei; Lu, Xiaolan; Shi, Haitao; Xu, Bing; Zhong, Wenting; Ma, Lin; Wang, Shuhui; Yang, Caifeng; He, Xinyi; Zhao, Yidi; Wang, Shenhao.
Afiliación
  • Hou Y; Department of Gastroenterology, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, 710004, China.
  • Dong L; Pulmonary and Critical Care Medicine, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, 710004, China.
  • Lu X; Department of Gastroenterology, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, 710004, China.
  • Shi H; Department of Gastroenterology, Shanghai Pudong Hospital, Shanghai, 201399, China.
  • Xu B; Department of Gastroenterology, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, 710004, China.
  • Zhong W; Department of Gastroenterology, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, 710004, China.
  • Ma L; International Medical Ward, Xi'an Jiaotong University Medical College First Affiliated Hospital, Xi'an, 710061, China.
  • Wang S; Department of Gastroenterology, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, 710004, China.
  • Yang C; Department of Gastroenterology, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, 710004, China.
  • He X; Departments of Gastroenterology, Xi'an City First Hospital, Xi'an, 710002, China.
  • Zhao Y; Department of Gastroenterology, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, 710004, China.
  • Wang S; Emergency Department, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, 710004, China.
Dig Dis Sci ; 67(12): 5580-5592, 2022 12.
Article en En | MEDLINE | ID: mdl-35879512
BACKGROUND AND AIMS: Recent studies have shown that changes in the intestinal microbiota contribute to the pathogenesis of irritable bowel syndrome (IBS). This study aimed to investigate the characteristics of the fecal and intestinal mucosal microbiota in IBS patients, and the correlation between microbiota and clinical manifestations. METHODS: Fecal and intestinal mucosal samples were collected from 14 constipation-predominant IBS (IBS-C) patients, 20 diarrhea-predominant IBS (IBS-D) patients, and 20 healthy controls (HCs). 16S rRNA gene sequencing and fluorescence in situ hybridization were used for the analysis of samples. RESULTS: Community richness and diversity of the fecal microbiota in IBS patients were significantly reduced compared with the HCs. The mucosal samples in IBS patients showed decreased Bifidobacterium and increased Bacteroides caccae compared with HCs; Eubacterium and Roseburia were decreased in IBS-C patients and increased in IBS-D patients. A comparison of the fecal and mucosal microbiota in IBS patients showed significantly increased Bifidobacterium in fecal samples and a decrease in mucosal samples in IBS-C patients; Bacteroides caccae and Roseburia were significantly reduced in fecal samples and increased in mucosal samples of IBS patients. A correlation between microbiota and clinical manifestations in IBS patients showed that Bacteroides caccae and Roseburia in fecal samples and Bifidobacterium and Eubacterium in mucosal samples were associated with abdominal pain and distention. CONCLUSIONS: Distinct differences exist between the fecal and intestinal mucosal microbiota in IBS patients, with the changes in the latter appearing more consistent with the pathophysiology of IBS. Changes in intestinal microbiota were associated with the clinical manifestations in IBS.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Síndrome del Colon Irritable / Microbiota / Microbioma Gastrointestinal Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Dig Dis Sci Año: 2022 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Síndrome del Colon Irritable / Microbiota / Microbioma Gastrointestinal Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Dig Dis Sci Año: 2022 Tipo del documento: Article País de afiliación: China