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Effects of comorbid posttraumatic stress disorder on cognitive dysfunction in Chinese male methamphetamine patients.
Jiang, Wei; Tian, Yang; Fan, Fusheng; Fu, Fabing; Wei, Dejun; Tang, Shanshan; Chen, Jiajing; Li, Yuqing; Zhu, Rongrong; Wang, Li; Shi, Zhanbiao; Wang, Dongmei; Zhang, Xiang-Yang.
Afiliación
  • Jiang W; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
  • Tian Y; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
  • Fan F; Xin Hua Drug Rehabilitation Center, Sichuan, China.
  • Fu F; Xin Hua Drug Rehabilitation Center, Sichuan, China.
  • Wei D; Xin Hua Drug Rehabilitation Center, Sichuan, China.
  • Tang S; Xin Hua Drug Rehabilitation Center, Sichuan, China.
  • Chen J; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
  • Li Y; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
  • Zhu R; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
  • Wang L; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
  • Shi Z; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address: shizb@psych.ac.cn.
  • Wang D; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address: wangdm@psych.ac.cn.
  • Zhang XY; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address: zhangxy@psych.ac.cn.
Prog Neuropsychopharmacol Biol Psychiatry ; 119: 110611, 2022 12 20.
Article en En | MEDLINE | ID: mdl-35907518
ABSTRACT

OBJECTIVES:

Cognitive dysfunction and posttraumatic stress disorder (PTSD) are common in methamphetamine patients. However, few studies have investigated the cognitive performance of methamphetamine patients with PTSD. The purpose of this study was to investigate the impact of comorbid PTSD on cognitive function in Chinese male methamphetamine patients.

METHODS:

We analyzed 464 methamphetamine patients and 156 healthy volunteers. The PTSD Screening Scale (PCL-5) was used to assess PTSD and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was used to assess cognitive function.

RESULTS:

Compared with healthy controls, methamphetamine patients had more cognitive dysfunction in immediate memory, visuospatial/constructional, language, attention and delayed memory. Moreover, methamphetamine patients with PTSD had less cognitive dysfunction in immediate memory, attention, and delayed memory than methamphetamine patients without PTSD. Further stepwise regression analysis showed that PTSD alterations in arousal and reactivity cluster were risk predictors for language, and PTSD negative alteration in cognition and mood cluster were risk predictors for delayed memory.

CONCLUSIONS:

Our results indicate that methamphetamine patients without PTSD have poorer cognitive dysfunction than those with PTSD. Some demographic and PTSD symptom clusters are protective or risk factors for cognitive dysfunction in methamphetamine patients.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Disfunción Cognitiva / Metanfetamina Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans / Male País/Región como asunto: Asia Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2022 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Disfunción Cognitiva / Metanfetamina Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans / Male País/Región como asunto: Asia Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2022 Tipo del documento: Article País de afiliación: China