MR imaging in children with transverse myelitis and acquired demyelinating syndromes.
Mult Scler Relat Disord
; 67: 104068, 2022 Nov.
Article
en En
| MEDLINE
| ID: mdl-35933757
ABSTRACT
BACKGROUND:
Transverse myelitis (TM) occurs isolated or within other acquired demyelinating syndromes (ADS) such as neuromyelitis optica spectrum disorders (NMOSD), multiple sclerosis (MS) or myelin oligodendrocyte glycoprotein antibody associated disorders (MOGAD).OBJECTIVE:
To describe and compare clinical and MRI features of children with ADS presenting with TM grouped according to antibody status and diagnosis of MS and NMOSD. PATIENTS ANDMETHODS:
Children with TM, radiological involvement of the myelon, MOG and aquaporin-4 antibody status were elegible.RESULTS:
100 children were identified and divided into MOGAD (n=33), NMOSD (n=7), double seronegative TM (n=34), and MS (n=26). MOGAD children had mainly acute disseminated encephalomyelitis + TM/ longitudinally extensive TM (LETM) (42%) or isolated LETM (30%). In MOGAD, LETM was present in more than half of all children (55%) with predominant involvement of only the grey matter (73%). Leptomeningeal enhancement was highly predictive of MOGAD (16/30; p=0.003). In MS patients spinal MRI showed single (50%) or multiple short lesions (46%) with involvement of grey and white matter (68%). Double seronegative children presented with LETM (74%) and brain lesions were less frequent compared to the other groups (30%).CONCLUSION:
Children with ADS presenting with TM reveal important radiological differences such as LETM with predominant involvement of spinal grey matter and leptomeningeal enhancement in MOGAD.Palabras clave
Texto completo:
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Banco de datos:
MEDLINE
Asunto principal:
Neuromielitis Óptica
/
Esclerosis Múltiple
/
Mielitis Transversa
Límite:
Humans
Idioma:
En
Revista:
Mult Scler Relat Disord
Año:
2022
Tipo del documento:
Article
País de afiliación:
Alemania