Reciprocal interplay between OTULIN-LUBAC determines genotoxic and inflammatory NF-&#954;B signal responses.

Li, Mingqi; Li, Ling; Asemota, Sarah; Kakhniashvili, David; Narayanan, Ramesh; Wang, Xusheng; Liao, Francesca-Fang

Reciprocal interplay between OTULIN-LUBAC determines genotoxic and inflammatory NF-κB signal responses.

Li, Mingqi; Li, Ling; Asemota, Sarah; Kakhniashvili, David; Narayanan, Ramesh; Wang, Xusheng; Liao, Francesca-Fang.

Afiliación

Li M; Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163.
Li L; Department of Biology, University of North Dakota, Grand Forks, ND 58202.
Asemota S; Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38103.
Kakhniashvili D; Proteomics & Metabolomics Core Facility, Office of Research, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163.
Narayanan R; Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38103.
Wang X; Department of Biology, University of North Dakota, Grand Forks, ND 58202.
Liao FF; Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163.

Proc Natl Acad Sci U S A ; 119(33): e2123097119, 2022 08 16.

Article en En | MEDLINE | ID: mdl-35939695

Asunto(s)

Daño del ADN; Enzimas Desubicuitinizantes; Endopeptidasas; Inflamación; FN-kappa B; Complejos de Ubiquitina-Proteína Ligasa; Enzimas Desubicuitinizantes/genética; Enzimas Desubicuitinizantes/metabolismo; Resistencia a Antineoplásicos; Endopeptidasas/genética; Endopeptidasas/metabolismo; Humanos; Inflamación/enzimología; Inflamación/genética; FN-kappa B/metabolismo; Necroptosis; Multimerización de Proteína; Transducción de Señal; Complejos de Ubiquitina-Proteína Ligasa/metabolismo; Ubiquitinación

Palabras clave

LUBAC; NF-κB; OTULIN; deubiquitinases; inflammation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Endopeptidasas / Daño del ADN / FN-kappa B / Complejos de Ubiquitina-Proteína Ligasa / Enzimas Desubicuitinizantes / Inflamación Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article

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