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Phototheranostics for multifunctional treatment of cancer with fluorescence imaging.
Yin, Xiaoran; Cheng, Yifan; Feng, Yan; Stiles, Wesley R; Park, Seung Hun; Kang, Homan; Choi, Hak Soo.
Afiliación
  • Yin X; Department of Oncology, The Second Affiliate Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Cheng Y; Department of Oncology, The Second Affiliate Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.
  • Feng Y; Department of Oncology, The Second Affiliate Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.
  • Stiles WR; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Park SH; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Kang H; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: hkang7@mgh.harvard.edu.
  • Choi HS; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: hchoi12@mgh.harvard.edu.
Adv Drug Deliv Rev ; 189: 114483, 2022 10.
Article en En | MEDLINE | ID: mdl-35944585
ABSTRACT
Phototheranostics stem from the recent advances in nanomedicines and bioimaging to diagnose and treat human diseases. Since tumors' diversity, heterogeneity, and instability limit the clinical application of traditional diagnostics and therapeutics, phototheranostics, which combine light-induced therapeutic and diagnostic modalities in a single platform, have been widely investigated. Numerous efforts have been made to develop phototheranostics for efficient light-induced antitumor therapeutics with minimal side effects. Herein, we review the fundamentals of phototheranostic nanomedicines with their biomedical applications. Furthermore, the progress of near-infrared fluorescence imaging and cancer treatments, including photodynamic therapy and photothermal therapy, along with chemotherapy, immunotherapy, and gene therapy, are summarized. This review also discusses the opportunities and challenges associated with the clinical translation of phototheranostics in pan-cancer research. Phototheranostics can pave the way for future research, improve the quality of life, and prolong cancer patients' survival times.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fotoquimioterapia / Nanopartículas / Neoplasias Límite: Humans Idioma: En Revista: Adv Drug Deliv Rev Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fotoquimioterapia / Nanopartículas / Neoplasias Límite: Humans Idioma: En Revista: Adv Drug Deliv Rev Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos