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Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key intermediate sterol that supports a branched ergosterol biosynthetic pathway.
Feng, Mei; Jin, Yiru; Yang, Sihyung; Joachim, Arline M; Ning, Yu; Mori-Quiroz, Luis M; Fromm, Jacob; Perera, Chamani; Zhang, Kai; Werbovetz, Karl A; Wang, Michael Zhuo.
Afiliación
  • Feng M; Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS, USA.
  • Jin Y; Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS, USA.
  • Yang S; Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS, USA.
  • Joachim AM; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
  • Ning Y; Department of Biological Sciences, Texas Tech University, Lubbock, TX, 79409, USA.
  • Mori-Quiroz LM; Synthetic Chemical Biology Core Laboratory, The University of Kansas, Lawrence, KS, USA.
  • Fromm J; Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS, USA.
  • Perera C; Synthetic Chemical Biology Core Laboratory, The University of Kansas, Lawrence, KS, USA.
  • Zhang K; Department of Biological Sciences, Texas Tech University, Lubbock, TX, 79409, USA.
  • Werbovetz KA; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
  • Wang MZ; Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS, USA. Electronic address: michael.wang@ku.edu.
Int J Parasitol Drugs Drug Resist ; 20: 27-42, 2022 Dec.
Article en En | MEDLINE | ID: mdl-35994895
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Parásitos / Leishmania Límite: Animals / Humans Idioma: En Revista: Int J Parasitol Drugs Drug Resist Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Parásitos / Leishmania Límite: Animals / Humans Idioma: En Revista: Int J Parasitol Drugs Drug Resist Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos