Cascades of Evolved Enzymes for the Synthesis of Complex Molecules.
Angew Chem Int Ed Engl
; 61(39): e202208358, 2022 09 26.
Article
en En
| MEDLINE
| ID: mdl-36026546
ABSTRACT
Thanks to advances in enzyme discovery and protein engineering combined with the development of enzymatic multistep reaction cascades, new efficient routes for drug synthesis have been created that are superior to chemical syntheses. This supports the goal of the chemical and pharmaceutical industries to move to more sustainable and environmentally friendly processes. Recently described outstanding examples include the biocatalytic cascade syntheses of the cyclic dinucleotide MK-1454, molnupiravir, and islatravir, as well as the efficient fixation of CO2 to make starch using an artificial enzyme cascade.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Dióxido de Carbono
/
Ingeniería de Proteínas
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2022
Tipo del documento:
Article
País de afiliación:
Alemania