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Lambert-Eaton Myasthenic Syndrome Recurrence Induced by Pembrolizumab in a Patient with Non-small-cell Lung Cancer.
Takigawa, Yuki; Watanabe, Hiromi; Omote, Yoshio; Kurihara, Sunao; Inoue, Tomoyoshi; Fujiwara, Miho; Mitsumune, Sho; Onishi, Kiriko; Kudo, Kenichiro; Sato, Akiko; Sato, Ken; Fujiwara, Keiichi; Shibayama, Takuo.
Afiliación
  • Takigawa Y; Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.
  • Watanabe H; Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.
  • Omote Y; Department of Neurology, National Hospital Organization Okayama Medical Center, Japan.
  • Kurihara S; Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.
  • Inoue T; Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.
  • Fujiwara M; Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.
  • Mitsumune S; Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.
  • Onishi K; Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.
  • Kudo K; Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.
  • Sato A; Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.
  • Sato K; Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.
  • Fujiwara K; Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.
  • Shibayama T; Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.
Intern Med ; 62(7): 1055-1058, 2023 Apr 01.
Article en En | MEDLINE | ID: mdl-36047125
ABSTRACT
A 73-year-old woman in complete remission from localized small-cell lung cancer associated with Lambert-Eaton myasthenic syndrome (LEMS) 22 years earlier was referred to our hospital and diagnosed with non-small-cell lung cancer. After three courses of pembrolizumab, an immune checkpoint inhibitor, the patient complained of muscle weakness, fatigue, ptosis, and dysarthria. The anti-voltage-gated calcium channel antibody level was elevated, and waxing was observed on a high-frequency repetitive stimulation test using an electromyogram. We diagnosed her with recurrence of LEMS as an immune-related adverse event (irAE) induced by pembrolizumab. After intravenous immunoglobulin therapy, the patient's symptoms improved, and she was discharged.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Síndrome Miasténico de Lambert-Eaton / Carcinoma de Pulmón de Células no Pequeñas / Carcinoma Pulmonar de Células Pequeñas / Neoplasias Pulmonares Límite: Aged / Female / Humans Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2023 Tipo del documento: Article País de afiliación: Japón
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Síndrome Miasténico de Lambert-Eaton / Carcinoma de Pulmón de Células no Pequeñas / Carcinoma Pulmonar de Células Pequeñas / Neoplasias Pulmonares Límite: Aged / Female / Humans Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2023 Tipo del documento: Article País de afiliación: Japón