Diagnostic value of miR-101 levels in blood and urine of patients with hypertensive disorder complicating pregnancy.
Clin Exp Hypertens
; : 1-7, 2022 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-36047533
ABSTRACT
OBJECTIVES:
This study explored the miR-101 clinical significance in hypertensive disorder complicating pregnancy (HDCP).METHODS:
Pregnant women with gestational hypertension (GH)/mild preeclampsia (mPE)/severe preeclampsia (sPE) were included. The miR-101 levels were measured. Correlation between miR-101 and soluble fmslike tyrosine kinase-1 (sFlt-1), miR-101 predictive value, and factors influencing HDCP grade were evaluated.RESULTS:
Serum miR-101 was down-regulated and negatively correlated with sFlt-1. miR-101 was an independent risk factor for HDCP and decreased with HDCP severity. The area under the curve of miR-101 in differentiating GH from mPE and mPE from sPE was 0.7764 and 0.8529.CONCLUSION:
Serum miR-101 level may be a biomarker for grading HDCP.
Texto completo:
1
Banco de datos:
MEDLINE
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Clin Exp Hypertens
Año:
2022
Tipo del documento:
Article
País de afiliación:
China