Early life adversity, reproductive history and breast cancer risk.
Evol Med Public Health
; 10(1): 429-438, 2022.
Article
en En
| MEDLINE
| ID: mdl-36101671
ABSTRACT
Background and objectives:
Individuals who experience early life adversity are at an increased risk for chronic disease later in life. Less is known about how early life factors are associated with cancer susceptibility. Here, we use a life history framework to test whether early life adversity increases the risk of breast cancer. We predict that early life adversity can shift investment in somatic maintenance and accelerate the timing of reproduction, which may mediate or interact with the risk of breast cancer.Methodology:
We use population-wide data from the Utah Population Database (UPDB) and Utah Cancer Registry, leading to 24â957 cases of women diagnosed with breast cancer spanning 20 years (1990-2010) and 124â785 age-matched controls. We generated a cumulative early life adversity summation score to evaluate the interaction (moderation) and mediation between early life adversity, reproductive history and their association with breast cancer risk.Results:
Our analyses led to three keyfindings:
(i) more early life adversity, when considered as a main effect, accelerates the time to first birth and death, (ii) early age at first birth and high parity decreases the risk of breast cancer and (iii) we find no association between early adversity and breast cancer risk either as a main effect or in its interaction with reproductive history. Conclusion and implications Early adversity elevates the risk of overall mortality through mechanisms other than breast cancer risk. This suggests early life factors can generate different effects on health. Future work should incorporate more complex view of life history patterns, including multiple life stages, when making predictions about cancer susceptibility.
Texto completo:
1
Banco de datos:
MEDLINE
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Evol Med Public Health
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos