Deficiency of the circadian clock gene Rev-erb&#945; induces mood disorder-like behaviours and dysregulation of the serotonergic system in mice.

Otsuka, Tsuyoshi; Le, Hue Thi; Thein, Zaw Lin; Ihara, Hayato; Sato, Fuyuki; Nakao, Tomomi; Kohsaka, Akira

Deficiency of the circadian clock gene Rev-erbα induces mood disorder-like behaviours and dysregulation of the serotonergic system in mice.

Otsuka, Tsuyoshi; Le, Hue Thi; Thein, Zaw Lin; Ihara, Hayato; Sato, Fuyuki; Nakao, Tomomi; Kohsaka, Akira.

Afiliación

Otsuka T; Faculty of Applied Biological Sciences, Gifu University, Gifu, 501-1193, Japan; The Second Department of Physiology, Wakayama Medical University, Wakayama 641-8509, Japan. Electronic address: t_otsuka@gifu-u.ac.jp.
Le HT; The Second Department of Physiology, Wakayama Medical University, Wakayama 641-8509, Japan; Department of Biomedical Engineering, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.
Thein ZL; The Second Department of Physiology, Wakayama Medical University, Wakayama 641-8509, Japan.
Ihara H; The Department of Radioisotope Laboratory Center, Wakayama Medical University, Wakayama 641-8509, Japan.
Sato F; Department of Diagnostic Pathology, Shizuoka Cancer Center, Suntogun, Shizuoka 411-8777, Japan; The Departments of Pathology, Wakayama Medical University, Wakayama 641-8509, Japan.
Nakao T; The Second Department of Physiology, Wakayama Medical University, Wakayama 641-8509, Japan; The First Department of Internal Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.
Kohsaka A; The Second Department of Physiology, Wakayama Medical University, Wakayama 641-8509, Japan.

Physiol Behav ; 256: 113960, 2022 11 01.

Article en En | MEDLINE | ID: mdl-36115382

Asunto(s)

Relojes Circadianos; Animales; Relojes Circadianos/genética; Ritmo Circadiano/genética; Humanos; Ratones; Ratones Noqueados; Miembro 1 del Grupo D de la Subfamilia 1 de Receptores Nucleares/genética; Miembro 1 del Grupo D de la Subfamilia 1 de Receptores Nucleares/metabolismo; Serotonina

Palabras clave

Clock gene; Mice; Mood disorders; Rev-erbα; Serotonergic system

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Relojes Circadianos Límite: Animals / Humans Idioma: En Revista: Physiol Behav Año: 2022 Tipo del documento: Article

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