Improving cancer immunotherapy by rationally combining oncolytic virus with modulators targeting key signaling pathways.

Zhu, Zhi; McGray, A J Robert; Jiang, Weijian; Lu, Binfeng; Kalinski, Pawel; Guo, Zong Sheng

Zhu, Zhi; McGray, A J Robert; Jiang, Weijian; Lu, Binfeng; Kalinski, Pawel; Guo, Zong Sheng.

Afiliación

Zhu Z; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
McGray AJR; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jiang W; Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Lu B; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Kalinski P; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Guo ZS; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.

Mol Cancer ; 21(1): 196, 2022 10 12.

Article en En | MEDLINE | ID: mdl-36221123

Asunto(s)

Neoplasias; Viroterapia Oncolítica; Virus Oncolíticos; Antígeno B7-H1; Receptores ErbB; Histona Desacetilasas; Humanos; Inmunoterapia; Quinasas de Proteína Quinasa Activadas por Mitógenos; Neoplasias/patología; Nucleotidiltransferasas; Virus Oncolíticos/genética; Fosfatidilinositol 3-Quinasas; Receptor de Muerte Celular Programada 1; Proteínas Proto-Oncogénicas c-akt; Proteínas Proto-Oncogénicas p21(ras); Transducción de Señal; Serina-Treonina Quinasas TOR; Proteína p53 Supresora de Tumor

Palabras clave

Antitumor immunity; Combination regimen; Efficacy; Immuno-oncology; Inhibitor; Oncolytic virus; Signaling pathway; Small molecule; Targeted therapy

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Virus Oncolíticos / Viroterapia Oncolítica / Neoplasias Límite: Humans Idioma: En Revista: Mol Cancer Asunto de la revista: NEOPLASIAS Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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