Site-Specific Radioiodination of Oligonucleotides with a Phenolic Element in a Programmable Approach.
Molecules
; 27(19)2022 Sep 23.
Article
en En
| MEDLINE
| ID: mdl-36234794
ABSTRACT
Radioiodination of oligonucleotides provides an extra modality for nucleic acid-based theranostics with potential applications. Herein, we report the design and synthesis of a phosphoramidite embedded with a phenolic moiety and demonstrate that oligonucleotides can be readily functionalized with phenol as a precursor by general DNA synthesis. It was identified that the introduction of the precursor does not block the specificity of an aptamer, and the radioiodination is applicable to both DNA and RNA oligonucleotides in a site-specific approach with a commercial kit.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Oligonucleótidos
/
Ácidos Nucleicos
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
China