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Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Rais, Rana; Lemberg, Kathryn M; Tenora, Lukás; Arwood, Matthew L; Pal, Arindom; Alt, Jesse; Wu, Ying; Lam, Jenny; Aguilar, Joanna Marie H; Zhao, Liang; Peters, Diane E; Tallon, Carolyn; Pandey, Rajeev; Thomas, Ajit G; Dash, Ranjeet P; Seiwert, Tanguy; Majer, Pavel; Leone, Robert D; Powell, Jonathan D; Slusher, Barbara S.
Afiliación
  • Rais R; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Lemberg KM; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Tenora L; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Arwood ML; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Pal A; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Alt J; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Wu Y; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Prague 16000, Czech Republic.
  • Lam J; The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
  • Aguilar JMH; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Zhao L; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Peters DE; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Tallon C; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Pandey R; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Thomas AG; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Dash RP; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Seiwert T; The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
  • Majer P; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Leone RD; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Powell JD; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Slusher BS; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Sci Adv ; 8(46): eabq5925, 2022 11 18.
Article en En | MEDLINE | ID: mdl-36383674
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Neoplasias Límite: Humans Idioma: En Revista: Sci Adv Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Neoplasias Límite: Humans Idioma: En Revista: Sci Adv Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos