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PDCM Finder: an open global research platform for patient-derived cancer models.
Perova, Zinaida; Martinez, Mauricio; Mandloi, Tushar; Gomez, Federico Lopez; Halmagyi, Csaba; Follette, Alex; Mason, Jeremy; Newhauser, Steven; Begley, Dale A; Krupke, Debra M; Bult, Carol; Parkinson, Helen; Groza, Tudor.
Afiliación
  • Perova Z; European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Martinez M; European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Mandloi T; European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Gomez FL; European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Halmagyi C; European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Follette A; European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Mason J; European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Newhauser S; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
  • Begley DA; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
  • Krupke DM; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
  • Bult C; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
  • Parkinson H; European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Groza T; European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Nucleic Acids Res ; 51(D1): D1360-D1366, 2023 01 06.
Article en En | MEDLINE | ID: mdl-36399494
PDCM Finder (www.cancermodels.org) is a cancer research platform that aggregates clinical, genomic and functional data from patient-derived xenografts, organoids and cell lines. It was launched in April 2022 as a successor of the PDX Finder portal, which focused solely on patient-derived xenograft models. Currently the portal has over 6200 models across 13 cancer types, including rare paediatric models (17%) and models from minority ethnic backgrounds (33%), making it the largest free to consumer and open access resource of this kind. The PDCM Finder standardises, harmonises and integrates the complex and diverse data associated with PDCMs for the cancer community and displays over 90 million data points across a variety of data types (clinical metadata, molecular and treatment-based). PDCM data is FAIR and underpins the generation and testing of new hypotheses in cancer mechanisms and personalised medicine development.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Límite: Child / Humans Idioma: En Revista: Nucleic Acids Res Año: 2023 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Límite: Child / Humans Idioma: En Revista: Nucleic Acids Res Año: 2023 Tipo del documento: Article