Effect of low-dose atropine eyedrops on pupil metrics: results after half a year of treatment and cessation.
Graefes Arch Clin Exp Ophthalmol
; 261(4): 1177-1186, 2023 Apr.
Article
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| MEDLINE
| ID: mdl-36401652
ABSTRACT
PURPOSE:
To evaluate the effect of low-dose atropine eyedrops on pupil metrics.METHODS:
This study was based on a randomized, double-masked, placebo-controlled, and cross-over trial in mainland China. In phase 1, subjects received 0.01% atropine or placebo once nightly. After 1 year, the atropine group switched to placebo (atropine-placebo group), and the placebo group switched to atropine (placebo-atropine group). Ocular parameters were measured at the crossover time point (at the 12th month) and the 18th month.RESULTS:
Of 105 subjects who completed the study, 48 and 57 children were allocated into the atropine-placebo and placebo-atropine groups, respectively. After cessation, the photopic pupil diameter (PD) and mesopic PD both decreased (- 0.46 ± 0.47 mm, P < 0.001; - 0.30 ± 0.74 mm, P = 0.008), and the constriction ratio (CR, %) increased (4.39 ± 7.54, P < 0.001) compared with values at the crossover time point of the atropine-placebo group; pupil metrics of the atropine-placebo group had no difference from the values at the crossover time point of the placebo-atropine group. After 6 months of treatment, the photopic PD and the mesopic PD increased (0.54 ± 0.67 mm, P < 0.001; 0.53 ± 0.89 mm, P < 0.001), the CR (%) decreased (- 2.53 ± 8.64, P < 0.001) compared with values at the crossover time point of the placebo-atropine group. There was no significant relationship between pupil metrics and myopia progression during 0.01% atropine treatment.CONCLUSION:
Pupil metrics and the CR could return to pre-atropine levels after cessation. Pupil metrics had no significant effect on myopia progression during treatment.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Atropina
/
Miopía
Tipo de estudio:
Clinical_trials
Límite:
Child
/
Humans
Idioma:
En
Revista:
Graefes Arch Clin Exp Ophthalmol
Año:
2023
Tipo del documento:
Article
País de afiliación:
China