Cellular distribution of IDH mutations in AML during morphologic remission.
Leuk Res
; 124: 106993, 2023 01.
Article
en En
| MEDLINE
| ID: mdl-36459762
ABSTRACT
Limited information exists about the cellular distribution of mutations which persist in remission in acute myeloid leukemia (AML) (variably considered pre-leukemic mutations). We hypothesized that mutations detectable in all cell compartments may be less pathogenic than those that are myeloid-restricted. Here, we describe the cellular compartments that have IDH mutations in five patients with IDH-mutated AML in morphologic remission. Unlike pre-leukemic clones harboring the more common DNMT3A, TET2 and ASXL1 (DTA) mutations, we show that IDH mutations are myeloid-restricted. This finding provides an explanation for the reports that IDH mutations carry a higher risk for relapse than DTA mutations. Detailed analysis of one case also shows acquisition of additional mutations in distinct cellular compartments, illustrating subclonal complexity associated with therapeutics.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Leucemia Mieloide Aguda
/
ADN (Citosina-5-)-Metiltransferasas
Límite:
Humans
Idioma:
En
Revista:
Leuk Res
Año:
2023
Tipo del documento:
Article