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Prediction of inotropic effect based on calcium transients in human iPSC-derived cardiomyocytes and machine learning.
Yang, Hongbin; Obrezanova, Olga; Pointon, Amy; Stebbeds, Will; Francis, Jo; Beattie, Kylie A; Clements, Peter; Harvey, James S; Smith, Graham F; Bender, Andreas.
Afiliación
  • Yang H; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, UK.
  • Obrezanova O; Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Pointon A; Functional and Mechanistic Safety, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Stebbeds W; Screening Profiling and Mechanistic Biology, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Francis J; Mechanistic & Structural Biology, AstraZeneca, Cambridge, UK.
  • Beattie KA; Target and Systems Safety, Non-Clinical Safety, In Vivo/In Vitro Translation, GlaxoSmithKline, Ware, UK.
  • Clements P; Pathology UK, Non-Clinical Safety, In Vivo/In Vitro Translation, GlaxoSmithKline, Ware, UK.
  • Harvey JS; Target and Systems Safety, Non-Clinical Safety, In Vivo/In Vitro Translation, GlaxoSmithKline, Ware, UK.
  • Smith GF; Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Bender A; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, UK. Electronic address: ab454@cam.ac.uk.
Toxicol Appl Pharmacol ; 459: 116342, 2023 01 15.
Article en En | MEDLINE | ID: mdl-36502871

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos / Células Madre Pluripotentes Inducidas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Toxicol Appl Pharmacol Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos / Células Madre Pluripotentes Inducidas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Toxicol Appl Pharmacol Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido