Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors.
J Neuroimmunol
; 374: 578009, 2023 01 15.
Article
en En
| MEDLINE
| ID: mdl-36508930
ABSTRACT
Central nervous system (CNS) tumors are the most common type of solid tumors in children and the leading cause of cancer deaths in ages 0-14. Recent advances in the field of tumor biology and immunology have underscored the disparate nature of these distinct CNS tumor types. In this review, we briefly introduce pediatric CNS tumors and discuss various components of the TME, with a particular focus on myeloid cells. Although most studies regarding myeloid cells have been done on adult CNS tumors and animal models, we discuss the role of myeloid cell heterogeneity in pediatric CNS tumors and describe how these cells may contribute to tumorigenesis and treatment response. In addition, we present studies within the last 5 years that highlight human CNS tumors, the utility of various murine CNS tumor models, and the latest multi-dimensional tools that can be leveraged to investigate myeloid cell infiltration in young adults and children diagnosed with select CNS tumors.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias del Sistema Nervioso Central
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Microambiente Tumoral
Límite:
Adolescent
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Animals
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Child
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Child, preschool
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Humans
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Infant
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Newborn
Idioma:
En
Revista:
J Neuroimmunol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos