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Small nonfunctional pancreatic neuroendocrine neoplasms: Time for a step-up treatment approach?
Rimbas, Mihai; Rizzatti, Gianenerico; Tosoni, Alberto; Impagnatiello, Michele; Panzuto, Francesco; Larghi, Alberto.
Afiliación
  • Rimbas M; Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Department of Gastroenterology, Colentina Clinical Hospital; Department of Internal Medicine, Carol Davila University of Medicine, Bucharest, Romania.
  • Rizzatti G; Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Tosoni A; Department of Internal Medicine, Gastroenterology and Hepatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Impagnatiello M; Department of Internal Medicine, Gastroenterology and Hepatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Panzuto F; Department of Medical-Surgical Sciences and Translational Medicine, Digestive Disease Unit, ENETS Center of Excellence, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy.
  • Larghi A; Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Endosc Ultrasound ; 12(1): 1-7, 2023.
Article en En | MEDLINE | ID: mdl-36510866
Surgery has been regarded as the only curative treatment for patients with small nonfunctional pancreatic neuroendocrine neoplasms (NF-PNENs) less than 2 cm. Due to the significant adverse event rates of surgery, the European Neuroendocrine Tumor Society issued guidelines favoring surveillance for those patients lacking criteria suggestive of an aggressive disease. Despite the above recommendations, a significant proportion of small NF-PNEN patients still undergo surgery. Recently, several studies have reported the safety and effectiveness of EUS-guided radiofrequency ablation (RFA) for the treatment of small NF-PNENs. The experience with EUS-RFA is, however, limited, but published results indicate a potential role as a minimally invasive alternative treatment for these patients, in particular in those in whom further progression is more probable, before they reach the absolute need for surgery. A step-up approach with EUS-RFA followed by surgery for the failure cases can become a valid option to be validated in clinical studies.
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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Endosc Ultrasound Año: 2023 Tipo del documento: Article País de afiliación: Rumanía

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Endosc Ultrasound Año: 2023 Tipo del documento: Article País de afiliación: Rumanía