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Magnetization transfer saturation reveals subclinical optic nerve injury in pediatric-onset multiple sclerosis.
Longoni, Giulia; Martinez Chavez, Edgar; Young, Kimberly; Brown, Robert A; Bells, Sonya; Fetco, Dumitru; Kim, Laura; Grover, Stephanie A; Costello, Fiona; Reginald, Arun; Bar-Or, Amit; Marrie, Ruth Ann; Arnold, Douglas L; Narayanan, Sridar; Branson, Helen M; Banwell, Brenda L; Sled, John G; Mabbott, Donald J; Yeh, E Ann.
Afiliación
  • Longoni G; Division of Neurology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada/Department of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
  • Martinez Chavez E; Department of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
  • Young K; Division of Neurology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
  • Brown RA; ShadowLab Research Inc., Toronto, ON, Canada.
  • Bells S; Department of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
  • Fetco D; McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
  • Kim L; Department of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
  • Grover SA; Division of Neurology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
  • Costello F; Departments of Clinical Neurosciences and Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Reginald A; Department of Ophthalmology and Visual Sciences, The University of Toronto, Toronto, ON, Canada.
  • Bar-Or A; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Marrie RA; Departments of Internal Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
  • Arnold DL; McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada/Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
  • Narayanan S; McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
  • Branson HM; Department of Diagnostic Imaging, University of Toronto, Toronto, ON, Canada.
  • Banwell BL; Division of Neurology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Sled JG; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Mabbott DJ; Department of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
  • Yeh EA; Division of Neurology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada/Department of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
Mult Scler ; 29(2): 212-220, 2023 02.
Article en En | MEDLINE | ID: mdl-36545918
ABSTRACT

BACKGROUND:

The presence of subclinical optic nerve (ON) injury in youth living with pediatric-onset MS has not been fully elucidated. Magnetization transfer saturation (MTsat) is an advanced magnetic resonance imaging (MRI) parameter sensitive to myelin density and microstructural integrity, which can be applied to the study of the ON.

OBJECTIVE:

The objective of this study was to investigate the presence of subclinical ON abnormalities in pediatric-onset MS by means of magnetization transfer saturation and evaluate their association with other structural and functional parameters of visual pathway integrity.

METHODS:

Eleven youth living with pediatric-onset MS (ylPOMS) and no previous history of optic neuritis and 18 controls underwent standardized brain MRI, optical coherence tomography (OCT), Magnetoencephalography (MEG)-Visual Evoked Potentials (VEPs), and visual battery. Data were analyzed with mixed effect models.

RESULTS:

While ON volume, OCT parameters, occipital MEG-VEPs outcomes, and visual function did not differ significantly between ylPOMS and controls, ylPOMS had lower MTsat in the supratentorial normal appearing white matter (-0.26 nU, p = 0.0023), and in both in the ON (-0.62 nU, p < 0.001) and in the normal appearing white matter of the optic radiation (-0.56 nU, p = 0.00071), with these being positively correlated (+0.57 nU, p = 0.00037).

CONCLUSIONS:

Subclinical microstructural injury affects the ON of ylPOMS. This may appear as MTsat changes before being detectable by other currently available testing.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neuritis Óptica / Traumatismos del Nervio Óptico / Esclerosis Múltiple Tipo de estudio: Prognostic_studies Límite: Adolescent / Child / Humans Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neuritis Óptica / Traumatismos del Nervio Óptico / Esclerosis Múltiple Tipo de estudio: Prognostic_studies Límite: Adolescent / Child / Humans Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Canadá