Dearomatizing [2+2+1] Spiroannulation of Indoles with Alkynes.
Org Lett
; 25(1): 261-266, 2023 Jan 13.
Article
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| MEDLINE
| ID: mdl-36546773
ABSTRACT
A palladium-catalyzed dearomatizing [2+2+1] spiroannulation of indoles with two molecular internal alkynes is developed in the presence of Cu(OAc)2/O2 as the oxidant, in which a domino sequence including C-H activation of indole followed by consecutive Heck reactions is involved. A range of 3,3'-spiroindolines bearing tetrasubstituted cyclopentadiene moieties and exocyclic CâC bonds at C2 are obtained in moderate to excellent yields.
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Banco de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2023
Tipo del documento:
Article
País de afiliación:
China