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SARS-CoV-2 Omicron (B.1.1.529) Infection of Wild White-Tailed Deer in New York City.
Vandegrift, Kurt J; Yon, Michele; Surendran Nair, Meera; Gontu, Abhinay; Ramasamy, Santhamani; Amirthalingam, Saranya; Neerukonda, Sabarinath; Nissly, Ruth H; Chothe, Shubhada K; Jakka, Padmaja; LaBella, Lindsey; Levine, Nicole; Rodriguez, Sophie; Chen, Chen; Sheersh Boorla, Veda; Stuber, Tod; Boulanger, Jason R; Kotschwar, Nathan; Aucoin, Sarah Grimké; Simon, Richard; Toal, Katrina L; Olsen, Randall J; Davis, James J; Bold, Dashzeveg; Gaudreault, Natasha N; Dinali Perera, Krishani; Kim, Yunjeong; Chang, Kyeong-Ok; Maranas, Costas D; Richt, Juergen A; Musser, James M; Hudson, Peter J; Kapur, Vivek; Kuchipudi, Suresh V.
Afiliación
  • Vandegrift KJ; Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA.
  • Yon M; The Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Surendran Nair M; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Gontu A; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Ramasamy S; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Amirthalingam S; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Neerukonda S; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Nissly RH; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Chothe SK; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Jakka P; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • LaBella L; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Levine N; United States Department of Health and Human Services, Silver Spring, MD 20993, USA.
  • Rodriguez S; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Chen C; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Sheersh Boorla V; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Stuber T; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Boulanger JR; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Kotschwar N; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Aucoin SG; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Simon R; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
  • Toal KL; Department of Animal Science, The Pennsylvania State University, University Park, PA 16802, USA.
  • Olsen RJ; Department of Animal Science, The Pennsylvania State University, University Park, PA 16802, USA.
  • Davis JJ; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Bold D; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
  • Gaudreault NN; National Veterinary Services Laboratories, Veterinary Services, U.S. Department of Agriculture, Ames, IA 50010, USA.
  • Dinali Perera K; White Buffalo, Inc., Chester, CT 06412, USA.
  • Kim Y; White Buffalo, Inc., Chester, CT 06412, USA.
  • Chang KO; City of New York Parks & Recreation, New York, NY 10029, USA.
  • Maranas CD; City of New York Parks & Recreation, New York, NY 10029, USA.
  • Richt JA; City of New York Parks & Recreation, New York, NY 10029, USA.
  • Musser JM; Laboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, TX 77030, USA.
  • Hudson PJ; Departments of Pathology and Laboratory Medicine and Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021, USA.
  • Kapur V; Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60637, USA.
  • Kuchipudi SV; Division of Data Science and Learning, Argonne National Laboratory, Argonne, IL 60439, USA.
Viruses ; 14(12)2022 12 12.
Article en En | MEDLINE | ID: mdl-36560774
ABSTRACT
There is mounting evidence of SARS-CoV-2 spillover from humans into many domestic, companion, and wild animal species. Research indicates that humans have infected white-tailed deer, and that deer-to-deer transmission has occurred, indicating that deer could be a wildlife reservoir and a source of novel SARS-CoV-2 variants. We examined the hypothesis that the Omicron variant is actively and asymptomatically infecting the free-ranging deer of New York City. Between December 2021 and February 2022, 155 deer on Staten Island, New York, were anesthetized and examined for gross abnormalities and illnesses. Paired nasopharyngeal swabs and blood samples were collected and analyzed for the presence of SARS-CoV-2 RNA and antibodies. Of 135 serum samples, 19 (14.1%) indicated SARS-CoV-2 exposure, and 11 reacted most strongly to the wild-type B.1 lineage. Of the 71 swabs, 8 were positive for SARS-CoV-2 RNA (4 Omicron and 4 Delta). Two of the animals had active infections and robust neutralizing antibodies, revealing evidence of reinfection or early seroconversion in deer. Variants of concern continue to circulate among and may reinfect US deer populations, and establish enzootic transmission cycles in the wild this warrants a coordinated One Health response, to proactively surveil, identify, and curtail variants of concern before they can spill back into humans.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ciervos / COVID-19 Límite: Animals / Humans País/Región como asunto: America do norte Idioma: En Revista: Viruses Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ciervos / COVID-19 Límite: Animals / Humans País/Región como asunto: America do norte Idioma: En Revista: Viruses Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos