Do trace elements influence the course of newly diagnosed type 1 diabetes mellitus?
Neuro Endocrinol Lett
; 43(5): 247-256, 2022 Dec 20.
Article
en En
| MEDLINE
| ID: mdl-36584401
ABSTRACT
OBJECTIVE:
The etiology of type 1 diabetes mellitus (DM1) is not fully understood. Some studies indicate an excess or deficiency of certain trace elements may affect glucose and insulin metabolism. This study aimed to assess the concentrations of trace elements in children with newly diagnosed DM1. The study group comprised 35 children aged 3-17 years (mean, 8.83±3.55 years). Serum concentrations of selenium, zinc, copper, and arsenic were determined at the time of diagnosis, after ~2 weeks (during insulin treatment), and after 6 months. No trace element deficiency was observed. Selenium levels were increased at all time points (77.61±14.03 µg/l; 70.42±11.04 µg/l; 75.79±12.89 µg/l). Arsenic levels were increased at the time of discharge (0.30±0.24 µg/l) and upon 6 months control visit (0.67±1.98 µg/l) for DM1. Copper levels were elevated at the time of diagnosis (1333±244 µg/l). No significant differences were observed in zinc concentrations between study and control group or between time points. Trace elements in the environment, especially selenium, may increase the incidence of DM1, although further research is required to confirm this association.
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Banco de datos:
MEDLINE
Asunto principal:
Arsénico
/
Selenio
/
Oligoelementos
/
Diabetes Mellitus Tipo 1
/
Insulinas
Tipo de estudio:
Diagnostic_studies
Límite:
Child
/
Humans
Idioma:
En
Revista:
Neuro Endocrinol Lett
Año:
2022
Tipo del documento:
Article
País de afiliación:
Polonia